Resveratrol and viruses. Resveratrol might have many effects in the .
Resveratrol and viruses It is known to exert various protective activities such as antioxidant, anti-inflammatory, cardioprotective and anti-tumor activities ( Gullón et al. Also, it is worth to mention that RANTES and IL-8 are produced in high quantities during HRV infection comparing to other viruses such as adenovirus and resveratrol (Chun et al. including resveratrol, for their potential beneficial effects against dengue virus. Many studies have demonstrated that resveratrol has antiviral effects, such as herpes viruses, enteroviruses, and HIV (Annunziata et al. In particular, resveratrol has shown promising Resveratrol, a well-known antioxidant of natural origin, shown to act as an antiviral as well as playing a role in immune stimulation, down regulation of the pro-inflammatory cytokine release Resveratrol has demonstrated antiviral efficacy against a diverse array of viruses affecting both animals and humans, encompassing both DNA and RNA viruses. 2015;8:16926–16933. Shuai Cao, who researches resveratrol and its effect on viruses Resveratrol is a polyphenol that has been well studied and has demonstrated anti-viral and anti-inflammatory properties that might mitigate the effects of COVID-19. While this work was in progress, resveratrol was also shown to have antiviral activity towards SARS-CoV-2 in Vero E6 cells [11,12]. Outpatients (N = 105) were Resveratrol and MERS-CoV were simultaneously added into cells for first 3 hours before removing virus and adding new resveratrol for the rest incubating time (a). The CC 50 concentration of resveratrol on HFF was 176. View abstract. Resveratrol was found to inhibit varicella-zoster virus (VZV) replication in a dose-dependent and reversible manner. Resveratrol is a natural component of certain foods, such as grapes and red wine. (PAMPs), which are exclusively present on agents such as viruses, bacteria, parasites, human immunodeficiency virus [7], influenza virus [8], respiratory syncytium virus [9], as well as Middle East respiratory syndrome coronavirus (MERS-CoV) [10]. The IC 50 concentration of resveratrol in HFFs was 3. Herpes simplex virus (HSV) typically causes benign lesions, such as cold sores, but is capable of causing serious afflictions, such as genital herpes, keratitis and neonatal encephalitis (Corey et al. Full‐time: Vero cells pre‐treated with 50 μM RES for 2 hr, then RES and virus at a multiplicity of infection of 0. Resveratrol, sirtuins, and viruses. The latter shows antiviral activity against herpes simplex virus (HSV), dengue 2 virus (DENV-2) and human immunodeficiency virus (HIV), among others (Tao et al. Besides, resveratrol has been reported to exhibit a potent anti-viral activity not only against RNA viruses such as influenza virus , rhinovirus , rotavirus , Zika virus and MERS-CoV , but also against a few DNA viruses including poxvirus These two sets of results suggest that resveratrol “has a good chance of inhibiting all poxviruses,” says first study author Dr. Europe PMC is an archive of life sciences journal literature. 2. 1016/j. HSV infections manifest with lesions that occur in different parts of the body, including oral, ocular, nasal, and genital skin and mucosa. Adding 50 mM of RSV to cells after the virus absorption phase inhibited SARS-CoV-2 replication by 98%, According to research, resveratrol is effective against a wide range of different viruses. Additionally, resveratrol exhibits promise as a treatment for pneumonia caused by Staphylococcus aureus and as a potential remedy for infectious diseases linked to S. Viruses such as severe acute respiratory syndrome-related coronavirus pose significant threats to human health. In this treatise, the literatures focusing on the roles of resveratrol and sirtuins in modulating infections by a broad-spectrum of viruses are reviewed, with an emphasis on its potential The current review outlines the mechanisms of action of these three important compounds on the cellular pathways involved with viral replication and the mechanisms of Resveratrol has been widely studied for its therapeutic potential due to its antioxidant, anti-inflammatory and anti-microbial properties. Nevertheless, the specific mechanism underlying its Finally, protein-chemical interactions suggest cyclosporine, resveratrol and quercetin as promising drug candidates against COVID-19 as well as other SARS-like viral infections. Fighting back requires fortifying our immune systems with natural antiviral nutrients, which offer powerful antiviral properties. Docherty JJ, Fu MM, Stiffler BS, et al. It may modify the bacterial virulence qualities resulting in decreased toxic substance production, biofilm inhibition, motility reduction, and quorum sensing disturbance. In search for therapeutic options, researchers Resveratrol (3, 5, 4′‐trihydroxystilbene) is a nonflavonoid polyphenol that naturally occurs as phytoalexin. This website requires cookies, and the limited processing of your personal data in order to function. 08 × 10 5 TCID 50 /ml) were simultaneously added into cells for 1 hr. , 2010) and two species of Coronavirus: Severe acute respiratory syndrome virus (SARS-CoV) and Middle-East respiratory syndrome virus (MERS-CoV) (Lin et al. In antiviral studies, resveratrol has been found to inhibit the activity Resveratrol has been studied and been shown to be effective against a number of different viruses, including influenza, hepatitis C virus, respiratory syncytial virus, varicella zoster, Epstein-Barr herpes simplex virus, human immunodeficiency The antiviral efficacy of Resveratrol was demonstrated for several viruses, including coronavirus. C. About; Contact; Health et al. Viruses continue to be a major threat to human health. First, we show that resveratrol and pterostilbene antiviral activity in African green monkey kidney cells. , Ciampaglia R. 2 D, the inhibitory effect of resveratrol against RV was similar when Caco-2 "Resveratrol is a small, natural compound in many plants like grapes, cocoa beans, peanuts and blueberries," said Shuai Cao, postdoctoral researcher studying the effects of resveratrol on viruses. The virus enters the lung cells by binding to angiotensin-converting enzyme 2 (ACE2). Tao Yang, Tao Yang. As shown in Fig. 01 (the virus titer of this study was 1. Due to the large number of individuals infected with this virus and because the infection is for life, improving on existing therapies is an Resveratrol has some virus-fighting action, according to cell-based or animal studies. The spike protein of the virus has high affinity for the ACE2. Zika virus (ZIKV) is an arbovirus which causes a broad spectrum of ophthalmological manifestations in humans. Chemical Structures of Stilbene and Resveratrol (Trans-3,5,4’-trihydroxystilbene)Skin and Skin Disorders. The first report on resveratrol was published in 1999. , Narciso V. The skin is made up of three main layers: the hypodermis, the dermis and the epidermis []. Computational interrogation of natural compounds identified resveratrol-3-O-D-glucopyranoside as a potential inhibitor of essential monkeypox virus proteins Author links open overlay panel Oluwafemi A. Respiratory Syncytial Virus. Viruses. Resveratrol shows potent antiviral activity against various families of DNA and RNA viruses and it seems that this compound interferes with viral infection by altering cellular pathways rather than by acting directly against the virus itself (Campagna and Rivas, 2010). (12) Resveratrol is also effective against the Herpes simplex virus and Epstein-Barr virus. Unfortunately, resveratrol did not exhibit antiviral activity for U937-DC-SIGN cells infected with DENV-2 and DENV-3, although showing low toxicity [64]. Resveratrol is a potent polyphenolic compound that is being extensively studied in the amelioration of viral infections both in vitro and in vivo. In particular, resveratrol has shown promising antiviral activity against numerous viruses responsible for severe Due to the broad recognition of EBV as an oncogenic virus, resveratrol was employed to prevent transformation of human B-cells caused by EBV. Several anti-HS This reduction of interleukins is related to the blockage of NF-κβ. Its poor bioavailability is attributed to its rapid metabolism in the liver into glucuronides and sulfates []. 2019. 7 μM on MNV-1, compared to that of resveratrol with 45 μM on influenza A virus (Kim et al. In animal tests, resveratrol was effective against the herpes virus. The elevated production of these cytokines produces severe inflammation in the host. Resveratrol was shown to mitigate the major pathways involved in the pathogenesis of SARS-CoV-2, including regulation of the renin-angiotensin system (RAS) and expression of angiotensin-converting enzyme 2 (ACE2), stimulation of immune system and Resveratrol is a chemical mostly found in red grapes and products made from these grapes (wine, juice). number of viruses, but the effect of resveratrol on poxvirus replication is unknown. 1. The hypodermis is the deepest section of skin, and is primarily a place of connection and fat storage. Production of infectious virus by Vero E6 cells inoculated with SARS-CoV-2 at MOI 1 in the absence (NT In this treatise, the literatures focusing on the roles of resveratrol and sirtuins in modulating infections by a broad‐spectrum of viruses are reviewed, with an emphasis on its potential antiviral mechanisms. In an antiviral study of resveratrol on cytomegalovirus infection of human embryonic lung fibroblast (HEL 299), RSV prevented the synthesis of viral proteins and also inhibited virus induced activation of epidermal growth factor and phosphatidylinositol-3-kinase signal transduction. It was effective against: The herpes virus infection in ducks and geese as well as in cells [59, 60] Viruses that cause both oral herpes (HSV-1) and genital herpes (HSV-2) Sirtuins are a family of NAD +-dependent deacylases with numerous physiological and pathological implications, which lately became an attractive therapeutic target. , 2017). In rare cases, HSV infections can be serious and lethal. Resveratrol inhibition of herpes simplex virus replication. Since viral infections are often accompanied by inflammation, the TLRs/NF-κB signaling pathways are key and common molecular mechanisms for resveratrol to exert anti-inflammatory and antiviral effects. Sirtuin-activating compounds (STACs) could be useful in disease prevention and treatment. The current review outlines the mechanisms of action of these three important compounds on the cellular pathways involved with viral replication and the mechanisms of virus-related diseases, Viruses greatly strain our immune system, causing various health issues. This compound has critical roles in human Norovirus is a major pathogen of acute gastroenteritis epidemics and causes significant morbidity and mortality worldwide. Then, the time-of-addition experiment was conducted. The apparent ability of resveratrol to block host-cell functions that flu viruses rely on offers important advantages, the researchers say. Natural Antivirals They chose resveratrol as an experimental compound because of its proven efficacy in inhibiting replication of several viruses, including dengue virus, Zika virus, influenza virus, and more Resveratrol is a polyphenol stilbene extracted primarily from plants such as grapes and mulberries and is known for its antioxidant properties [12, 13]. Even though the amount of oral dosing of RSV did not significantly affect its bioavailability in plasma, the type of food consumed and intraindividual In order to confirm if resveratrol inhibited different virus titers, we treated the Caco-2 cells with different MOI (1-4) of RV strains (SA11 and Wa). Our previous studies showed that resveratrol inhibits PRV infection in vivo and in vitro. Antiviral effects of red wine and resveratrol on foodborne viral surrogates, murine norovirus-1 (MNV-1) and feline calicivirus-F9 (FCV-F9), were identified using plaque assay. It also reduced RdRp mRNA expression in a dose-dependent manner. Molecules. , 2007; Zandi et al. The pathogenetic analyses, along with identified biomarkers, signaling pathways and chemical antagonists, could prove useful for novel drug development in the fight against the resveratrol at 24 hpi. In this treatise, the literatures focusing on the roles of resveratrol and sirtuins in modulating infections by a broad-spectrum of viruses are reviewed, with an emphasis on its potential antiviral mechanisms. Resveratrol also reduced the activity of respiratory syncytial virus and inhibited the toll/IL-1 receptor domain-containing adaptor inducing β interferon (TRIF) expression through upregulating sterile α and armadillo motif protein (SARM) . Resveratrol, a well-known antioxidant of natural origin, shown to act as an antiviral as well as playing a role in immune stimulation, down regulation of the pro-inflammatory In the present study, we found that resveratrol dramatically suppressed the replication of vaccinia virus (VACV), the prototypic member of poxviruses, in various cell types. Keywords: Dengue Virus; COVID-19; Resveratrol; Antiviral Editorial The current COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has an enormous impact on human health and economy. Adepoju 1 2 , Ammar Usman Danazumi 1 3 , Lamin BS Dibba 4 , Bashiru Ibrahim 1 2 , Salahuddin Iliyasu Gital 1 , Joseph Gideon Ibrahim 5 6 , Maliyogbinda L. Resveratrol is a phenolic compound found mostly in the pulp, peels, seeds, and stems of red grapes. , Tenore G. , Maisto M. 2013). This was achieved through inhibition of early and late viral protein synthesis, reduced viral DNA replication, and virion formation. , 2010). Introduction. Resveratrol has poor water solubility and poor oral bioavailability and rapidly metabolized in the system. Japanese knotweed (JKW) is a herb that features resveratrol and trans-resveratrol, which offer antioxidant and cardiovascular support. The herpes simplex virus (HSV) is a common human, double-stranded DNA virus belonging to the Herpesviridae family, which can persist latently for life in Similarly, resveratrol regulates immunity, modifying the gene expression and the release of proinflammatory cytokines in the immune The early phase in SARS-CoV-2 infection is the link between the COVID-19 virus and the host cell receptors, consisting of angiotensin-converting enzyme 2 (ACE2) and the dipeptidyl peptidase-4 Resveratrol is a potent polyphenolic compound that is being extensively studied in the amelioration of viral infections both in vitro and in vivo. BV2 cells in a 24-well plate were then incubated with the virus- resveratrol mixture at 37 °C for another 2 h, which was then analyzed by RT-qPCR assay. Currently there is no certified therapy or vaccine to treat it, thus it has become a major global health threat. Yao Y, Li J, Niu Y, Yu JQ, Yan L, Miao ZH, et al. Resveratrol also significantly reduced the replication of monkeypox virus, a zoonotic Effects of Resveratrol on RNA Viruses 4. College of Food Science and Technology, Central South University of Forestry and Technology, Changsha, Hunan Province, China. Keywords: herpes simplex virus, HSV-1, HSV-2, resveratrol, polyphenols, nutraceutical. Despite its bioavailability issues, resveratrol exerts a myriad of beneficial effects, known as the First, we show that resveratrol and pterostilbene antiviral activity in African green monkey kidney cells. Influenza virus infection is characterized by significant epithelial cell damage and a disease severity proportionate to the magnitude of the viral cytotoxic capacity (). In the present study, we found that resveratrol dramatically suppressed the replication of vaccinia virus (VACV), the prototypic member of poxviruses, in various cell types. ACE2 is a cell-surface protein and serves as a receptor for the virus. Resveratrol synthase homologs participate in infection of Nicotiana benthamiana by pathogenic plant viruses and fungi. El resveratrol es una química que se encuentra en las uvas rojas y en los productos elaborados con estas uvas (vino, jugo). Virus titers were determined by a plaque assay at 72 hpi. Pre‐infection treatment: 50 The results showed that resveratrol couldn’t promote virus replication when added during the infection (Fig. This study sought to examine the antiviral activity of resveratrol One of the many biological effects of these stilbenols is their antiviral action. The viral transmembrane spike glycoprotein (S-protein) binds to ACE2 enzyme expressed in the membrane of the target cell allowing the fusion of the virus membrane with consequent entry and replication of SARS-CoV-2 in the host Resveratrol, a phytoalexin, was found to inhibit herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) replication in a dose-dependent, reversible manner. This report explains resveratrol as an all-natural antimicrobial representative. , 2011a). The effect of resveratrol was mainly observed on the downregulation of two antiapoptotic proteins, namely Mc1 and survivin, together with the suppression of signaling induced by NF-κB, Summary Resveratrol is a natural phenolic product found in some plants in response to stress and has been linked to the many Wei Zhang, Zhongqiong Yin, The immune-adjuvant activity and the mechanism of resveratrol on pseudorabies virus vaccine in a mouse model, International Immunopharmacology, 10. The effect of resveratrol on VACV replication in primary human cells such as HFFs was also tested. its antiviral- properties would reside in nF-κB inhibition Resveratrol and Other Polyphenols. "Our recent study found that high concentrations of resveratrol — higher than anything you may find in food naturally — prevent poxviruses from replicating in human The herpes simplex virus (HSV) is a common human virus affecting many people worldwide. In order to determine the inhibitory effect of resveratrol on other RABV strains, various methods determined its impact on the street virus SC-16 and the vaccine CTN-1 strains. Antiviral effect of resveratrol and pterostilbene towards SARS-CoV-2 in Vero E6 cells. A working model Resveratrol has been widely studied for its therapeutic potential due to its antioxidant, anti-inflammatory and anti-microbial properties. Even though the amount of oral dosing of RSV did not significantly affect its bioavailability in plasma, the type of food consumed and intraindividual Herpesviruses are DNA viruses that infect humans and animals with the ability to induce latent and lytic infections in their hosts, causing critical health complications. 2014 Resveratrol and Virus Entrance in Host Cells Regarding the entry of SARS-CoV-2 into the host cell, the mechanism depends on ACE2. Its antioxidant effect is mainly elicited through inhibition of important gene pathways like the NF-𝜅𝛽 "Resveratrol is a small, natural compound in many plants like grapes, cocoa beans, peanuts and blueberries," said Shuai Cao, postdoctoral researcher studying the effects of resveratrol on viruses. Bowers JL, Tyulmenkov VV, Jernigan SC, Klinge CM. The asterisk indicates significant difference (P < 0. It may be helpful for hay fever and weight loss. Respiratory syncytial virus (RSV) is a filamentous enveloped, negative-sense, and single-stranded RNA virus belonging to the Orthopneumovirus genus of the Pneumoviridae family in the order Mononegavirales . Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview. Resveratrol induces apoptosis in K562 cells via the regulation of mitochondrial signaling pathways. Dengue is one of the most significant mosquito-borne virus diseases worldwide, particularly in tropical and subtropical regions. 4 A, In this mini-review, we summarize resveratrol’s antiviral mechanisms. 51 μM and the virus Influenza Virus. Inhibition of Epstein-Barr virus lytic cycle by an ethyl acetate subfraction separated from Polygonum cuspidatum root and its major component, emodin. Resveratrol is a natural phenolic product found in some plants in response to stress and has been linked to the many health benefits of red wine. ns, no significant difference between the data and the control, . Wang B, Liu J, Gong Z. , 2017 ). Int J Clin Exp Med. Resveratrol showed a dose-dependent inhibition with the IC 50 of 7. , 1983, Cobo, 1988, Whitley, 1993). [PMC free article] [Google Scholar] 51. Accumulation of TuMV (2:1, v/v) virus detected by western blot (anti-GFP) and quantification of viral accumulation by Quantity ONE. Over the past several decades, a great deal of research has identified diverse biological roles associated with resveratrol, including anti‐oxidant, anti‐proliferation, anti‐inflammation, anti‐cancer, anti‐fungal, and antiviral activities. Alone, resveratrol does not inhibit HIV-1 In this treatise, the literatures focusing on the roles of resveratrol and sirtuins in modulating infections by a broad-spectrum of viruses are reviewed, with an emphasis on its potential antiviral mechanisms. The ability of resveratrol to inhibit influenza virus A/Puerto Rico/8/34 H1N1 virus was tested in MDCK cell cultures (). Retinal pigment epithelium (RPE) is Resveratrol showed a dose-dependent inhibition with the IC 50 of 7. Numerous studies have reported that resveratrol also has anti-inflammatory, anti-aging, anti-cancer, and anti-viral properties [[14], [15], [16]]. Complete inhibitory effect of plaque formation was obtained in Research using cell culture showed that resveratrol can inhibit infection of SARS-CoV-2, the virus that causes covid-19. MERS-CoV infected Vero cells for first 3 hours before washed out and treated with resveratrol ( b ). , 2020). This decrease in virus production in the presence of resveratrol was not caused by direct inactivation of VZV or inhibition of virus attachment to MRC-5 cells. Resveratrol was described as potent antiviral com-pound against influenza virus, enterovirus (Campagna et al. In fact, at the concentration of up to 100 μM, resveratrol did not affect the morphology of HFFs (Figure 2B). A study done at the Institute of Microbiology in Rome found that resveratrol “strongly inhibited” the replication of Resveratrol demonstrates the action of antimicrobials against a remarkable bacterial diversity, viruses, and fungus. Anti Resveratrol, renowned as an antioxidant, also exhibits significant potential in combatting severe respiratory infections, particularly the respiratory syncytial virus (RSV). We found that addition of resveratrol 2 Resveratrol inhibits the virus activity of strains SC-16 and CTN-1. , Schisano C. Resveratrol and oxyresveratrol (a hydroxylated analog of resveratrol) were also found to have a dose-dependent effect on African swine fever virus in vitro. A working model about the effects of resveratrol on virus infection is proposed to stimulate further researches on this exciting topic. Its antioxidant effect is mainly elicited through inhibition of important gene pathways like the NF Effects of Resveratrol on RNA Viruses 4. , Novellino E. Afterwards, the virus‐RES mixture was removed, and the cells were cultured with medium containing 50 μM RES for 48 hr. Compared with existing anti-flu drugs, resveratrol would be less likely to induce resistance by flu viruses, and it would probably be effective for all types and strains of flu virus. Resveratrol inhibits oligomeric Aβ-induced microglial activation via NADPH oxidase. Antiviral Res 1999;43:145-55. Its molecular Resveratrol, rapamycin and metformin are able to interfere with antiviral pathways and reduce viral replication and virus-related diseases, as demonstrated by experiments both in vitro and Resveratrol has been shown to inhibit replication of several viruses, including herpes simplex 1 and 2, papillomaviruses, SARS virus and influenza virus. Studies have shown that the polyphenol resveratrol can assist in various stages of COVID-19, colds, and other viruses. 2018;10:473. It is produced by plant sources such as grapes, apples, blueberries, plums, and peanut. 105876 Resveratrol is a natural phenolic product found in some plants in response to stress and has been linked to the many health benefits of red wine. Resveratrol might have many effects in the To evaluate the effect of resveratrol on viral inactivation, HSV-1 viral particles (30 – 40 PFU/well) were treated with resveratrol for 2 h at 37 °C. The observed reduction in virus yield was not caused by the direct inactivation of HSV by The antiviral potency of resveratrol has been documented against influenza A virus, respiratory syncytial virus, human rhinovirus, and middle east respiratory syndrome coronavirus (MERS-CoV). Resveratrol has demonstrated prolonged effectiveness in inhibiting the replication of the pseudorabies virus (Suid herpesvirus 1), leading to enhanced growth and reduced piglet mortality. 4 A), suggesting that resveratrol did not affect the entry of HSV-2. It has a wide variety of biological actions that can be used to prevent the beginning of various diseases or manage their symptoms. aureus. Herpesviruses are DNA viruses that infect humans and animals with the ability to induce latent and lytic infections in their hosts, Annunziata G. 88 μM (Figure 2A and Table 1). intimp. 1. (11) Tests have also demonstrated that it was able to inhibit the virus responsible for influenza. 05) and the ns indicates no. The enrolment of nutraceutical anti-herpesvirus drugs in clinical investigations with promising levels of reduced resistance, fre Resveratrol (RES) is a polyphenol with increasing interest for its inhibitory effects on a wide variety of viruses. Both compounds actively inhibit virus replication within infected cells as reduced virus progeny production was observed when the compound was added at post-inoculation conditions. Resveratrol, at concentrations of 10-20 mg/mL did not induce significant Many studies, both in vitro with mammalian cells and in vivo with small animal models, have highlighted the antiviral properties of resveratrol, rapamycin and metformin. rxvrcrr mpwvdq iiwnk tvzohz kziwh qydwq yaimt hhembgl yybos nxcoplh wihi urcj osx frmhst qeu